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If oral steroids are required as a long-term treatment’such as in treatment of certain inflammatory disorders (eg, lupus, ankylosing spondylitis)’you should be aware of the following side effects that may occur with prolonged use: Slower wound healing and increased skin bruising Increased infection risk Clouding or blurred vision High blood sugar Osteoporosis and fractures Avascular necrosis of bone (death of bone due to lack of blood supply) Safely Using Oral Steroids for Spine Pain. Oral steroids are prescription-only medications. During your visit with your doctor, ask about the side effects and complications associated with these drugs. Also, make sure you understand exactly how to properly use your oral steroid, as it may be on a tapered schedule in contrast to a simple one-pill-per-day regimen. Safely using your drug means using it exactly as your doctor prescribes. 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